منابع مشابه
Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells
The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to overcome blood supply shortages. Here, we report that functional human erythrocytes can be efficiently produced from cord blood (CB) CD34+ cells using a bottle turning device culture system. Safety and efficiency studies were performed in mur...
متن کاملEx vivo production of red blood cells from human cord blood
Background Transfusion of red blood cells (RBC) is the only clinically effective therapeutic approach for treating oxygen transport deficits (i.e. blood loss in surgical interventions and anaemia). However potential shortage of transfusable RBC has been predicted for the near future as a result of an imbalance between supply and demand due to aging population, an increase in the transmission of...
متن کاملPlasticity of Cells and Ex Vivo Production of Red Blood Cells
The supply of transfusable red blood cells (RBCs) is not sufficient in many countries. If transfusable RBCs could be produced abundantly from certain resources, it would be very useful. Our group has developed a method to produce enucleated RBCs efficiently from hematopoietic stem/progenitor cells present in umbilical cord blood. More recently, it was reported that enucleated RBCs could be abun...
متن کاملEx Vivo Generated Red Cells as Transfusion Products
This issue of the Stem Cell International journal contains papers from many of the leading scientists in the emerging field: ex vivo expansion of hematopoietic progenitor cells into erythrocytes for transfusion. Blood transfusion, the first form of successful cell therapy and, at least to some, " transplantation " , was inspired by the discovery of the circulation by Richard Harvey in the 1600s...
متن کاملEx Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells on Collagen- Fibronectin Coated Electrospun Nano Scaffold
Background and Objective: Umbilical Cord blood (UCB) hematopoietic stem cell (HSC) transplantation is a therapeutic approach for the treatment of malignant and non-malignant hematologic disorders due to ease of collection, lack of risk for donors and lower levels of infection. Moreover, it is considered a good alternative for bone marrow HSC transplantation. The main limitation of their use is ...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-121117